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Staff Information
 
     
  John Cleary  
 

Ph.D Candidate

 
  Email: john.cleary@utoronto.ca  
     
  Research Interest/Responsibility  
     
  DNA replication and trinucleotide repeat instability  
     
  Publications  
     
Cleary JD, Tome S, Lopez Castle A, Panigrahi GB, Foiry L, Hagerman KA, Sroka H, Chitayat D, Gourdon G, Pearson CE. Tissue-and age-specific DNA replication patterns at the CTG/CAG-expanded human myotonic dystropy type 1 locus. Nature Structural Molecular Biology. 2010 September; 17(9):1079-87.
Lopez Castel A, Cleary JD, Pearson CE. Repeat instability as the basis for human diseases and as a potential target for therapy. Nature Reviews Molecular Cell Biology. 2010 March; 11(3):165-70
Libby RT, Hagerman KA, Pineda VV, Lau R, Cho DH, Baccam SL, Axford MM, Cleary JD, Moore JM, Sopher BL, Tapscott SJ, Filippova GN, Pearson CE, La Spada CTCF cis-regulates trinucleotide repeat instability in an epigenetic manner: a novel basis for mutation hot spot determination. PLoS Genetics. 2008 November; 4(11):e1000257.
Pearson CE, Nichol Edamura K, Cleary JD. Repeat instability: mechanisms of dynamic mutations. Nature Reviews Genetics. 2005 October; 6(10):729-42. Review.
Cleary JD, Pearson CE. Replication fork dynamics and dynamic mutations: the fork-shift model of repeat instability. Trends in Genetics. 2005 May; 21(5):272-80.
Cleary JD, Pearson CE. The contribution of cis-elements to disease-associated repeat instability: clinical and experimental evidence. Cytogenet Genome Research. 2003 October; 100(1-4):25-55. Review.
Cleary JD, Pearson CE. The contribution of cis-elements to disease-associated repeat instability: clinical and experimental evidence. Cytogenetic and Genome Research. 2003 January; 100(1-4):25-55
Pearson CE, Tam M, Wang YH, Montgomery SE, Dar AC, Cleary JD, Nichol K. Slipped-strand DNAs formed by long (CAG)*(CTG) repeats: slipped-out repeats and slip-out junctions. Nucleic Acids Research. 2002 October; 30(20):4534-47.
Cleary JD, Nichol Edamura K, Wang YH, Pearson CE. Evidence of cis-acting factors in replication-mediated trinucleotide repeat instability in primate cells. Nature Genetics. 2002 May; 31(1):37-46.
Panigrahi GB, Cleary JD, Pearson CE. In vitro (CTG)*(CAG) expansions and deletions by human cell extracts. Journal of Biological Chemistry. 2002 April; 277(16):13926-34.
     
 
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