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Staff Information
 
     
  Dr. Stephanie Tome  
 

Post-Doctoral Fellows

 
  Email: N/A  
     
  Research Interest/Responsibility  
     
  DNA replication on trinucleotide repeat instability  
     
  Publications  
     
Mason AG, Tomé S, Simard JP, Libby RT, Bammler TK, Beyer RP, Morton AJ, Pearson CE, La Spada AR. Expression levels of DNA replication and repair genes predict regional somatic repeat instability in the brain but are not altered by polyglutamine disease protein expression or age. Human Molecular Genetics 2014 Mar 15;23(6):1606-18.
Tomé S, Manley K, Simard JP, Clark GW, Slean MM, Swami M, Shelbourne PF, Tillier ER, Monckton DG, Messer A, Pearson CE MSH3 polymorphisms and protein levels affect CAG repeat instability in Huntington's disease mice. PLoS Genetics 2013;9(2):e1003280.
Tomé S, Simard JP, Slean MM, Holt I, Morris GE, Wojciechowicz K, te Riele H, Pearson CE Tissue-specific mismatch repair protein expression: MSH3 is higher than MSH6 in multiple mouse tissues. DNA Repair 2013 Jan 1;12(1):46-52
Tomé S, Panigrahi GB, López Castel A, Foiry L, Melton DW, Gourdon G, Pearson CE. Maternal germline-specific effect of DNA ligase I on CTG/CAG instability. Human Molecular Genetics 2011 Jun 1;20(11):2131-43.
López Castel A, Nakamori M, Tomé S, Chitayat D, Gourdon G, Thornton CA, Pearson CE. Expanded CTG repeat demarcates a boundary for abnormal CpG methylation in myotonic dystrophy patient tissues. Human Molecular Genetics. 2011 Jan 1;20(1):1-15.
Cleary JD, Tome S, Lopez Castle A, Panigrahi GB, Foiry L, Hagerman KA, Sroka H, Chitayat D, Gourdon G, Pearson CE. Tissue-and age-specific DNA replication patterns at the CTG/CAG-expanded human myotonic dystropy type 1 locus. Nature Structural Molecular Biology. 2010 September; 17(9):1079-87.
Tome S, Holt I, Edelmann W, Morris GE, Munnich A, Pearson CE, Gourdon G. MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice. PLoS Genetics. 2009 May; 5(5):e1000482.
     
 
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