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Staff Information
  Jodie Simard  

Research Technician

  Email: jodie.simard@sickkids.ca  
  Research Interest/Responsibility  
  Effects of drugs and DNA repair on trinucleotide repeat instability / Lab organization  
Mason AG, Tomé S, Simard JP, Libby RT, Bammler TK, Beyer RP, Morton AJ, Pearson CE, La Spada AR. Expression levels of DNA replication and repair genes predict regional somatic repeat instability in the brain but are not altered by polyglutamine disease protein expression or age. Human Molecular Genetics 2014 Mar 15;23(6):1606-18.
Hick A, Wattenhofer-Donzé M, Chintawar S, Tropel P, Simard JP, Vaucamps N, Gall D, Lambot L, André C, Reutenauer L, Rai M, Teletin M, Messaddeq N, Sch Neurons and cardiomyocytes derived from induced pluripotent stem cells as a model for mitochondrial defects in Friedreich\'s ataxia. Disease Models & Mechanisms 2013 May;6(3):608-21.
Tomé S, Manley K, Simard JP, Clark GW, Slean MM, Swami M, Shelbourne PF, Tillier ER, Monckton DG, Messer A, Pearson CE MSH3 polymorphisms and protein levels affect CAG repeat instability in Huntington's disease mice. PLoS Genetics 2013;9(2):e1003280.
Tomé S, Simard JP, Slean MM, Holt I, Morris GE, Wojciechowicz K, te Riele H, Pearson CE Tissue-specific mismatch repair protein expression: MSH3 is higher than MSH6 in multiple mouse tissues. DNA Repair 2013 Jan 1;12(1):46-52
Panigrahi GB, Slean MM, Simard JP, Pearson CE Human mismatch repair protein hMutLα is required to repair short slipped-DNAs of trinucleotide repeats. Journal of Biological Chemistry 2012 Dec 7;287(50):41844-50.
Seriola A, Spits C, Simard JP, Hilven P, Haentjens P, Pearson CE, Sermon K. Huntington\'s and myotonic dystrophy hESCs: down-regulated trinucleotide repeat instability and mismatch repair machinery expression upon differentiation. Human Molecular Genetics. 2011 Jan 1;20(1):176-85.
Panigrahi GB, Slean MM, Simard JP, Gileadi O, Pearson CE. Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired. Proceedings of the National Academy of Sciences of the United States of America. 2010 July; 107(28):12593-8.
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