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Staff Information
  Kaalak Reddy  

M.Sc candidate

  Email: kaalak.reddy@utoronto.ca  
  Research Interest/Responsibility  
  DNA repair on trinucleotide repeat instability  
Reddy K, Schmidt MH, Geist JM, Thakkar NP, Panigrahi GB, Wang YH, Pearson CE. Processing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability. Nucleic Acids Research 2014 Aug 21.
Zamiri B, Reddy K, Macgregor RB Jr, Pearson CE. TMPyP4 porphyrin distorts RNA G-quadruplex structures of the disease-associated r(GGGGCC)n repeat of the C9orf72 gene and blocks interaction of RNA-binding proteins. The Journal of Biological Chemistry 2014 Feb 21;289(8):4653-9.
Reddy K, Pearson CE RAN translation: fragile X in the running. Neuron 2013 May 8;78(3):405-8.
Reddy K, Zamiri B, Stanley SY, Macgregor RB, Pearson CE The disease-associated r(GGGGCC)n repeat from the C9ORF72 gene forms tract length-dependent uni- and multi-molecular RNA G-quadruplex structures. Journal of Biological Chemistry 2013 Apr 5;288(14):9860-6.
Slean MM, Reddy K, Wu B, Nichol Edamura K, Kekis M, Nelissen FH, Aspers RL, Tessari M, Schärer OD, Wijmenga SS, Pearson CE Interconverting Conformations of Slipped-DNA Junctions Formed by Trinucleotide Repeats Affect Repair Outcome. Biochemistry 2013 Feb 5;52(5):773-85
Reddy K, Tam M, Bowater RP, Barber M, Tomlinson M, Nichol Edamura K, Wang YH, Pearson CE. Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeats. Nucleic Acids Research. 2011 Mar;39(5):1749-62.
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