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Staff Information
  Rachel Lau  

Research Technician (Alumni)

  Email: rachel.lau@sickkids.ca  
  Research Interest/Responsibility  
  Effects of drugs and DNA repair on trinucleotide repeat instability / Lab organization  
Libby RT, Hagerman KA, Pineda VV, Lau R, Cho DH, Baccam SL, Axford MM, Cleary JD, Moore JM, Sopher BL, Tapscott SJ, Filippova GN, Pearson CE, La Spada CTCF cis-regulates trinucleotide repeat instability in an epigenetic manner: a novel basis for mutation hot spot determination. PLoS Genetics. 2008 November; 4(11):e1000257.
Panigrahi GB, Lau R, Montgomery SE, Leonard MR, Pearson CE. Slipped (CTG) (CAG) repeats can be correctly repaired, escape repair or undergo error-prone repair. Nature Structural Molecular Biology. 2005 August; 12(8):654-62.
Yang Z, Lau R, Marcadier JL, Chitayat D, Pearson CE. Replication inhibitors modulate instability of an expanded trinucleotide repeat at the myotonic dystrophy type 1 disease locus in human cells. American Journal of Human Genetics. 2003 November; 73(5):1092-105.
Libby RT, Monckton DG, Fu Y-H, Martinez RA, McAbney JP, Lau R, Einum DD, Nichol K, Ware CB, Ptacek LJ, Pearson CE, LaSpada AR. Genomic context drives SCA7 CAG repeat instability, while expressed SCA7 cDNAs are intergenerationally and somatically stable in transgenic mice. Human Molecular Genetics. 2003 January; 12(1):41-50.
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